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File:PegUricase.png

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English: A comparison of uricase (pdb:1uox) and PEG-uricase (model). PEG-uricase includes 40 polymers of 10kDa PEG. PEGylation improves its solubility at physiological pH, increases serum half-life and reduces immunogenicity without compromising activity. Upper images show the whole tetramer, lower images show an example of one of the lysines that is PEGylated. (PEG-uricase model from reference[1], only 36 PEG polymers included)
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Xigasho Shaqadayda
Qoraa Evolution and evolvability

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I, the copyright holder of this work, hereby publish it under the following license:
w:en:Creative Commons
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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  1. ↑ (3 January 2008). "PEG-uricase in the management of treatment-resistant gout and hyperuricemia.". Advanced drug delivery reviews 60 (1): 59-68. PMID 17826865.

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PEGylation Ingiriisi

pegloticase Ingiriisi

uricase Ingiriisi

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inception Ingiriisi

22 Febraayo 2015

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kan hadda23:50, 21 Febraayo 2015Sawirka yar nuuciisa ahaa 23:50, 21 Febraayo 20152,192 × 2,136 (1.65 MB)Evolution and evolvabilityUser created page with UploadWizard

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